Definition Stickler syndrome is a group of autosomal dominant hereditary conditions characterized by a distinctive, rather flattened, facial appearance, eye abnormalities, hearing loss, and joint problems. (Syphilis) Stickler syndrome is a disorder of the connective tissue, the tissue that supports or surrounds organs and other types of tissue. Etymology Hereditary progressive arthro-ophthalmodystrophy. Etiology Stickler Syndrome